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Raisins

Effects of Raisin Intake

The effect of minimal dietary changes with raisins in NAFLD patients with non-significant fibrosis: a randomized controlled intervention.


Abstract:

Aiming at investigating the potential effect of minimal dietary changes in NAFLD patients with non-significant fibrosis, 55 patients with NAFLD were enrolled in a randomized controlled clinical trial. Patients were assigned into two isocaloric dietary treatment groups for 24 weeks: (a) nutritional counseling (Control arm, N = 27), (b) nutritional counseling with currants included (two fruit servings, 36 g per day), substituting snacks of similar caloric content (Currant arm, N = 28). Clinical tests, anthropometrics, inflammatory and oxidative stress markers were conducted pre- and post-intervention. A total of 50 patients completed the trial. Significant differences between the two arms post-intervention were observed in fasting glucose and in IL-6 levels, these being significantly decreased only in Currant patients. Body weight, BMI, HbA, CRP and EUS values decreased in both arms, differences being insignificant between the two arms post-intervention. Participants in the Currant arm had significantly reduced total body fat, WC and trunk fat. Ultrasound scanning improved significantly in patients snacking currants daily. Also, volunteers enrolled in the Currant arm showed a reduced intake of saturated fatty acids. Because BW regulation has been officially recognized as a treatment approach in NAFLD an additional analysis was repeated in patients adhering to this. Post-intervention, the decrease in IL-6 and in fasting glucose was significantly higher in Currant patients who lost BW compared to their counterparts in the Control arm. Conclusively, minimal modifications in snacking choices, such as the inclusion of dried grapes in diet, are beneficial in NAFLD patients with non-significant fibrosis.

https://greenmedinfo.com/article/inclusion-dried-grapes-diet-was-beneficial-nafld-patients-non-significant-fibr


Effects of a Raisin Supplement on Cognitive Performance, Quality of Life, and Functional Activities in Healthy Older Adults-Randomized Clinical Trial.


Abstract:

The objective of this study was to evaluate the effects of consuming 50 g of raisins on cognitive performance, quality of life, and functional activities in healthy older adults. This is a parallel randomized controlled clinical trial, in which 80 subjects over 70 years of age participated. For 6 months, the intervention group (IG;= 40) consumed 50 g of raisins per day added to their usual diet, whereas the control group (CG;= 40) received no supplement. All variables were measured at baseline and at 6 months. Cognitive performance assessed with the Montreal Cognitive Assessment (MOCA) test shows a difference of 3.27 points (95% CI 1.59 to 4.96),≤0.001, favorable to the IG, after the intervention. Among the cognitive performances, an improvement is observed in the IG in orientation, assessed both with the MOCA test 0.49 (95% CI 0.10 to 0.87),= 0.014, and with the Mini-Mental State Examination (MMSE) test, 0.36 (95% CI 0.02 to 0.70),= 0.038. In visuospatial/executive capacity and in language, improvements were also observed in the IG, 1.36 (95% CI 0.77 to 1.95),= 0.001, and 0.54 points (95% CI 0.12 to 0.96),= 0.014, respectively. Immediate and delayed recall, assessed with the Rey Auditory Verbal Learning Test, improved in the IG. In addition, the IG showed a better quality of life and greater autonomy in instrumental activities of daily living after 6 months. No significant changes were observed in the rest of the variables analyzed. Therefore, the consumption of 50 g of raisins produces a slight improvement in cognitive performance, quality of life, and functional activities in the elderly.


https://greenmedinfo.com/article/consumption-50g-raisins-produces-slight-improvement-cognitive-performance-qual


Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines.


Abstract:

BACKGROUND: Raisins are a significant source of dietary fiber and polyphenols, which may reduce cardiovascular disease (CVD) risk by affecting lipoprotein metabolism and inflammation. Walking represents a low intensity exercise intervention that may also reduce CVD risk. The purpose of this study was to determine the effects of consuming raisins, increasing steps walked, or a combination of these interventions on blood pressure, plasma lipids, glucose, insulin and inflammatory cytokines.

RESULTS: Thirty-four men and postmenopausal women were matched for weight and gender and randomly assigned to consume 1 cup raisins/d (RAISIN), increase the amount of steps walked/d (WALK) or a combination of both interventions (RAISINS + WALK). The subjects completed a 2 wk run-in period, followed by a 6 wk intervention. Systolic blood pressure was reduced for all subjects (P = 0.008). Plasma total cholesterol was decreased by 9.4% for all subjects (P<0.005), which was explained by a 13.7% reduction in plasma LDL cholesterol (LDL-C) (P<0.001). Plasma triglycerides (TG) concentrations were decreased by 19.5% for WALK (P<0.05 for group effect). Plasma TNF-alpha was decreased from 3.5 ng/L to 2.1 ng/L for RAISIN (P<0.025 for time and group x time effect). All subjects had a reduction in plasma sICAM-1 (P<0.01).

CONCLUSION: This research shows that simple lifestyle modifications such as adding raisins to the diet or increasing steps walked have distinct beneficial effects on CVD risk.


https://greenmedinfo.com/article/simple-lifestyle-modifications-such-adding-raisins-diet-or-increasing-walking-


Antioxidant properties of raisins


Abstract:

Currants and sultanas (Vitis vinifera L., Family Vitaceae) are dried vine products produced in Greece and used widely in the Mediterranean diet. We investigated the polar methanol extracts from the raisins for the antiradical activity, polyphenol content, cytotoxicity in peripheral blood mononuclear cells, total glutathione (GSH) levels, oxidized glutathione (GSSG) levels, and inhibition of low-density lipoprotein (LDL) oxidation. Extracts exhibited 1,1-diphenyl-2-picrylhydrazyl scavenging activity and inhibited tert-butylhydroperoxide (tBHP)-induced cytotoxicity, GSH decrease, and LDL oxidation. Fluorescence microscopy revealed the characteristic apoptotic patterns with tBHP and inhibition with the extracts. Elevated levels of total GSH and unaltered levels of GSSG with extract treatment demonstrated the induction of gamma-glutamylcysteine synthetase. The antioxidant activity was correlated to the polyphenolic content. Greek currants and sultanas are suggested as antioxidant components of the Mediterranean basin.



https://greenmedinfo.com/article/antioxidant-properties-raisins


Consumption of selected varieties of raisins could confer a beneficial effect against gastric inflammatory diseases.


Abstract:

Raisins (Vitis vinifera L.) are dried grapes largely consumed as important source of nutrients and polyphenols. Several studies report health benefits of raisins, including anti-inflammatory and antioxidant properties, whereas the anti-inflammatory activity at gastric level of the hydro-alcoholic extracts, which are mostly used for food supplements preparation, was not reported until now. The aim of this study was to compare the anti-inflammatory activity of five raisin extracts focusing on Interleukin (IL)-8 and Nuclear Factor (NF)-κB pathway. Raisin extracts were characterized by High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD) analysis and screened for their ability to inhibit Tumor necrosis factor (TNF)α-induced IL-8 release and promoter activity in human gastric epithelial cells. Turkish variety significantly inhibited TNFα-induced IL-8 release, and the effect was due to the impairment of the corresponding promoter activity. Macroscopic evaluation showed the presence of seeds, absent in the other varieties; thus, hydro-alcoholic extracts from fruits and seeds were individually tested on IL-8and NF-κB pathway. Seed extract inhibited IL-8 and NF-κB pathway, showing higher potency with respect to the fruit. Although the main effect was due to the presence of seeds, the fruit showed significant activity as well. Our data suggest that consumption of selected varieties of raisins could confer a beneficial effect against gastric inflammatory diseases.


https://greenmedinfo.com/article/consumption-selected-varieties-raisins-could-confer-beneficial-effect-against-



Chemopreventive properties of raisins originating from Greece in colon cancer cells.


Abstract:

Colorectal cancer is one of the major causes of cancer-related mortality in humans in both developed and developing countries. Dietary patterns influence the risk of colon cancer development, while plant-derived foods have gained great interest, due to the high content of antioxidants. Corinthian raisins (Currants, CR) and Sultanas (S) (Vitis vinifera L., Vitaceae) are dried vine fruits produced in Greece with many culinary uses in both the Mediterranean and the Western nutrition. In the present study, we investigated the effects of CR and S on human colon cancer cells. Methanol extracts of CR and S were used at different concentrations. The total polyphenol content and anti-radical activity were measured by Folin-Ciocalteu and DPPH, respectively. Antioxidant, anti-inflammatory and anti-proliferative effects on HT29 cell culture were evaluated. All extracts exhibited DPPH˙ scavenging activity in a dose-dependent manner. Both products suppressed cell proliferation, while the levels of glutathione and cyclooxygenase 2 were significantly decreased. A significant reduction in IL-8 levels and NF-kappaB p65 activation was also observed. Both antioxidant and anti-inflammatory effects were dependent on the duration of exposure. Results indicate that the methanol extracts of CR and S exhibit anti-radical activity in vitro, as well as cancer preventive efficacy on colon cancer cells, with S having slightly higher activity. The beneficial properties of these unique dried grapes are attributed to their high content of phenolic compounds.


https://greenmedinfo.com/article/chemopreventive-properties-raisins-originating-greece-colon-cancer-cells




Greek raisins (Vitis vinifera L.) exhibit antiproliferative effects on gastric cancer cell growth.


Abstract:

urrants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as methanol extracts obtained from Sultanas cultivated in the island of Crete as to inhibition of cell proliferation, induction of apoptosis, and inhibition of inflammation. All extracts from 500 microg dried raisins studied suppressed cell proliferation, significantly those obtained from Sultanas from Crete and currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells indicated that Cretan Sultana, Nemea, and Messinia currants at 500 microg dried product/ml medium significantly induced cell death. All extracts from 500 microg dried raisins statistically decreased protein and mRNA levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8 protein levels and quantification for IL-8 mRNA showed no significant decrease. These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells.



https://greenmedinfo.com/article/greek-raisins-vitis-vinifera-l-exhibit-antiproliferative-effects-gastric-cance



Novel triterpenoids isolated from raisins exert potent antiproliferative activities by targeting mitochondrial and Ras/Raf/ERK signaling in human breast cancer cells.


Abstract:

Raisins are produced in many regions of the world and may be eaten raw or used in cooking, baking and brewing. Bioactivity-guided fractionation of raisins was used to determine the chemical identity of bioactive constituents. Seven triterpenoids, including three novel triterpenoids, were isolated and identified. The novel triterpenoids were elucidated to be 3β,13β-dihydroxy-12,13-dihydrooleanolic acid (1), 3β,12β,13β-trihydroxy-12,13-dihydrooleanolic acid (2, TOA), and 3β,13β-dihydroxy-12,13-dihydroursolic acid (7), respectively. TOA showed the highest antiproliferative activity against MCF-7/DOX cells, with an EC50 value of 3.60 ± 0.55 μM. Compounds 1, 3 and 7 also exhibited potent antiproliferative activity against MCF-7/DOX cells, with an EC50 value of 7.10 ± 0.65, 10.22 ± 0.90 and 8.91 ± 1.12 μM. Compounds 1 and 2 also exhibited potent antioxidant activities. Moreover, the detailed cytotoxic mechanisms of TOA were investigated bytargeting the mitochondrial and protein tyrosine kinase signaling (Ras/Raf/ERK). The results strongly demonstrated that the novel triterpenoids isolated from raisins could be promising candidates for therapy of breast cancer.


https://greenmedinfo.com/article/novel-triterpenoids-isolated-raisins-exert-potent-antiproliferative-activities


Phenolic contents of some disease-resistant raisins


Abstract

The evaluation of different fruit species and grapes by drying gains importance especially because of its high nutrient content and long-term preservation. In addition, due to increasing consumer and environmental awareness, consumers have more demand for raisins produced by using minimum chemical pesticides throughout the production process. In addition, due to the increasing importance of phenolic compounds for human health, the demand for high phenolic content cultivars and their products is increasing. In this study, 7 different grape cultivars (‘Mars Seedless’, ‘Campbell Early’, ‘Muscat Bleu’, ‘Kay Gray’, ‘Philipp’, ‘Kishmish Vatkana’, ‘Rhea’) which are tolerant or resistant to fungal diseases and grown with a reduced spraying program were studied. Grapes were obtained from the trial vineyard of Yalova Atatürk Horticulture Central Research Institute (Yalova, Turkey). After these cultivars were dried in an energy-saving heat pump dryer, the important phenolic compound contents were determined by HPLC method and the differences between the cultivars were revealed. As a result, the phenolic compounds of the raisins obtained by drying these grape cultivars, which can be grown in humid regions, in an energy-saving heat pump dryer were determined and the correlations between these compounds were determined. Thus, it has been determined in this study that raisins are an important source of polyphenols and that there may be significant differences between species or cultivars.



https://www.researchgate.net/publication/377261122_Phenolic_contents_of_some_disease-resistant_raisins_Vitis_spp



A study of the Chemical Composition, Vitamins and Minerals of Four Varieties of Raisins


Abstract and Figures

This study aimed to use four varieties of raisins (Iraqi, Turkish, Indian, and American). The chemical analysis showed that the American variety had a higher percentage of moisture and protein than the other two (26.30 and 16.68 percent, respectively), while the Indian variety had a higher percentage of ash and fiber (2.1 and 4.6 percent, respectively). The Turkish variety stood out for its higher fat content (1.2 percent), and the Iraqi variety had a higher carbohydrate content (67.86 percent). As for estimating the percentage of total vitamins (vitamin C and water-soluble vitamins group B), the results of estimating vitamin C in raisins showed the following results for the four varieties (2.99 mg / 100 g; 5.48 mg / 100 g; 7.60 mg / 100 g; 7.15 mg / 100 g), respectively, and the values of vitamin B group (B1 -- B2 - B3) in the four types of raisins, which were estimated using the HPLC device. 0.47 mg/100 g and 0.42 mg/100 g, respectively. The results of estimating the mineral elements (K, Na, Ca, Mg, Cu, Mn, Zn, and Fe) in the four raisin varieties showed that the potassium element K was recorded at the level of Potential 5% high ratios compared to the rest of the other elements, where the highest value was recorded for the Turkish variety (235 mg per 100 g) and the lowest value for the Iraqi variety (218 mg per 100 g). It was the highest value in the American variety and the lowest value in the Iraqi variety. As for calcium Ca, we note that it had the highest value in the American variety (46.02 mg per 100 g) and the lowest value in the Iraqi variety (39.05 mg per 100 g). While we find that the Iraqi and Turkish varieties recorded consecutive values for the Iraqi Mg element (19.05 mg/100 g), the Turkish (20.04 mg/100 g), as well as the Indian (22.09 mg/100 g), and the American (23.06 mg/100 g), As for the copper element Cu, we find that its value for the American variety (2.25 mg/100 g) recorded the highest values, and the Iraqi variety (1.22 mg/100 g) recorded the lowest values. As for the element manganese, Mn, it recorded low percentages in all varieties compared to the rest of the other elements. And for the iron element Fe, we note that the Indian variety (2.72 mg/100 g) has outperformed the other three varieties. As for the element Zn, we find its value in the Iraqi, Turkish, Indian, and American varieties. Significant differences were recorded between the varieties, as the highest value was recorded for the American variety (2.42 mg/100 g) and the lowest value for the Iraqi variety (1.17 mg/100 g).


https://www.researchgate.net/publication/376537199_A_study_of_the_Chemical_Composition_Vitamins_and_Minerals_of_Four_Varieties_of_Raisins


A Comprehensive review of Raisins and Raisin components and their relationship to human health


Abstract and Figures

Purpose: This literature review was performed to assess the effect of raisins on human health. Methods: A review of Medline was conducted using the keywords: 'raisins, raisins and health, raisins and cardiovascular disease (CVD), raisins and cancer, raisins and diabetes, raisins and fiber, raisins and colon health, raisins and antioxidants, raisins and inflammation, raisins and dental caries'. The reference lists from previous review articles on raisins and human health and the California Raisin Marketing Board files were reviewed for additional studies. Results: Raisins have one of the highest polyphenolic content and antioxidant ORAC levels compared to other traditional dried fruits. Many of the polyphenols in raisins are well assimilated and bioavailable. Raisin consumption reduces low density lipoprotein (LDL) cholesterol, blood pressure and blood sugar, when compared to equal caloric carbohydrate snacks and is associated with a reduced risk of CVD. The anti-inflammatory and cancer chemopreventive effects of raisins are mixed. Raisin consumption reduces intestinal transit time and positively affects gut microbiota. Raisins produce sustained energy during long term athletic competitions equal to traditional sports energy gels, shots and jelly beans. Raisins produce a non-cariogenic oral environment and do not fit the American Academy of Pediatrics criteria to be considered a choking hazard. Conclusions: Based on the review of literature, consumption of raisins provide numerous health benefits for promoting general wellness and in the prevention of many chronic diseases including: CVD, type 2 diabetes mellitus (T2DM) gastrointestinal diseases, and dental caries.


https://www.researchgate.net/publication/319062831_A_Comprehensive_review_of_Raisins_and_Raisin_components_and_their_relationship_to_human_health


Investigation of grape and raisin extracts in induction of apoptosis and necrosis and their genetic expression on cancer stem cells (SH-SY5Y)


Abstract and Figures

Grapes and raisins with and without seeds were extracted using ethyl acetate/H2O solvent. The antioxidant activity of each extract was confirmed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and free radical scavenging assay. The results confirmed the antioxidant property of the extract in such a way that the most antioxidant activity of the extract was on radical activity. Free radicals were observed in extracts of seedless raisins and seeded grapes. Their cytotoxicity was investigated on cancer stem cells (SHSY5Y) using the MTT (p-value = <0.0001) method. The results obtained from the MTT test were confirmed using the cell counting method and Trypan blue staining. Cells (SHSY5Y-1) were identified with IC50=66.87 µg/mL in seeded grapes extract and IC50=12.63 µg/mL in raisins without seeds extract. The FITC-V Annexin + and PI + cell populations were considered as secondary apoptosis, and FITC-V Annexib-and PI + cell populations as necrosis. Data analysis was done using device software. Flow cytometry analysis showed that 62.2 % of cells underwent cell apoptosis after treatment with seedless raisin extract and 78% of cells after treatment with seeded grapes. Real time PCR method was performed for the molecular analysis of treated cells. The change was evaluated in the expression of apoptotic genes (BAX, BCL2, P53, and GAPDH). Expression of apoptotic genes for BAX and BCL2 is high under treatment with seeded grape extract. However, the expression of apoptotic genes for BCL2 and P53 is high under treatment with raisin without grape extract.


https://www.researchgate.net/publication/380394289_Investigation_of_grape_and_raisin_extracts_in_induction_of_apoptosis_and_necrosis_and_their_genetic_expression_on_cancer_stem_cells_SH-SY5Y


Effects of Pretreatments and Drying Methods on Drying Kinetics and Physical properties of Raisins


Abstract

Drying is a process to convert grape berries into raisins. The waxy cuticle on the surface of grapes acts as a barrier against moisture evaporation during the drying process. Therefore, an effective pretreatment and drying method is necessary to remove the waxy layer to accelerate the drying rate. A study was conducted to standardize the effect of pretreatments viz., K 2 CO 3 with ethyl oleate and olive oil, hot water treatment and no dipping along with three drying methods viz., cabinet tray dryer, solar tunnel dryer and open sun drying on drying time, instrumental color value (L*, a*,b*) and texture (N) of raisins. Grapes berries (var. Thompson seedless) pretreated with ethyl oleate 1.5% + K 2 CO 3 3% and dried in cabinet tray dryer took lesser (26.08h) drying time and appeared lighter (47.04 L*), bright green (4.03 a*), intense yellow (27.98 b*) and were soft (4.91 N). Sun dried raisins without pretreatment took maximum (169h) drying time, more dark (25.87 L*), and observed to be stiff (6.44 N). The findings emphasize the pretreatment and drying method in minimizing the drying time with desirable color, nutritional qualities, organoleptic attributes. Therefore, the production of raisins using the above said treatment and drying method will have scope from both the industrial and health points of view, because of the remarkable reduction in the processing time and drying time.



https://www.researchgate.net/publication/366635146_Effects_of_Pretreatments_and_Drying_Methods_on_Drying_Kinetics_and_Physical_properties_of_Raisins




Is Eating Raisins Healthy?


Abstract

Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as well as the cell line and animal model studies carried out to date. It has been demonstrated that raisins possess a low-to-moderate glycemic index, which makes them a healthy snack. They seem to contribute to a better diet quality and may reduce appetite. Their antioxidant capacity has been correlated to the phenolic content and this may be involved in the improvement of cardiovascular health. In addition, raisins maintain a good oral health due to their antibacterial activity, low adherence to teeth and an optimum oral pH. Raisin consumption also seems to be favorable for colon function, although more studies should be done to conclude this benefit. Moreover, gut microbiota could be affected by the prebiotic content of raisins. Cell line and animal model studies show other potential benefits in specific diseases, such as cancer and Alzheimer's disease. However, deeper research is required and future intervention studies with humans are needed. Overall, incorporating an 80-90 g portion of raisins (half a cup) into the daily diet may be favorable for human health.



https://www.researchgate.net/publication/338213976_Is_Eating_Raisins_Healthy




Raisins with Clarified Butter or Ghee for The Relief Of Acute And Chronic Constipation -A Clinical Study


Abstract and Figures

Background: Constipation is a very distressful symptom, affecting to all age group. The only treatment is laxatives, which is having many adverse effects mainly dependency on laxatives. Purpose: To evaluate the laxative effect of raisins and to get relief from daily dependency on laxative medicines for acute and chronic constipation Methods: Interventional / Experimental study of raisins and clarified butter or ghee performed at 'Vishwaraj Hospital' Pune, Maharashtra, India from March 2021 to June 2021, after appropriate ethical approval obtained from the Vishwaraj Hospital's Ethics Committee (Registration number-ECR/1138/Inst/MH/2018). Fifty one patients of constipation who were on laxatives or PR enema enrolled in this study, diagnosis confirmed by gastro-enterologist. Laxatives had been asked to stop before enrollment. Questionnaire form were given at the time of enrollment and telephonic follow up for OPD patients and by visiting to admit patients had been taken on 2 nd day after consumption of raisins and clarified butter or ghee then on 7 th and 15 th day. Forms were collected once they were visit to their respective doctors for follow up. Results: Statistical tool used in this study is the 95 % confidence interval. The variables of interest were 1) percent of patients have restarted laxatives or not and 2) number of days required to get relief from constipation. 94.12 % of patients (n=48) did not restart laxatives after consumption of raisins and clarified butter or ghee and the population percent of patients that might not restart laxatives would be 88% to 100% with 95 % confidence. Also the number of days to get relief from constipation after consumption of raisins and clarified butter or ghee for a patient in population would be 3-4 days with 95 % confidence. Conclusion: Raisins and CB or ghee had given relief from acute and chronic constipation; worked very well on irritable bowel syndrome, fissure in ano, hemorrhoids and helped to stop PR bleeding and bloating causes by these diseases. Patients got relief from constipation on 3rd and 4th day. This study concluded that raisins with clarified butter or ghee can be taken instead of laxatives or enema to get relief from constipation; this might be the great substitute for laxatives and per rectum enema.


https://www.researchgate.net/publication/355406205_Raisins_with_Clarified_Butter_or_Ghee_for_The_Relief_Of_Acute_And_Chronic_Constipation_-A_Clinical_Study



A pilot, randomized controlled trial to examine the health outcomes of raisin consumption in patients with diabetes


abstract

Objectives: Dried fruits, like their fresh homologues, contain relatively high concentrations of an-

tioxidants. The aim of this study was to determine the health outcomes of raisin consumption on

patients with diabetes.

Methods: We examined the effects of dried grapes (Vitis vinifera) cultivated in Greece, namely

Corinthian Raisins (CR) on blood pressure, fasting glucose, glucated hemoglobin (HbA 1c ), lipid

peroxidation, high-sensitivity C-reactive protein, antioxidant status, and cytokines in patients with type 2 diabetes mellitus (T2DM). Forty-eight well-controlled patients with T2DM from the diabetes outpatient clinic of our hospital were recruited to a two-armed, randomized, controlled, 24-wk prospective intervention trial in order to examine the health outcomes of CR consumption. All participants were reported to consume less fruits and vegetables than the recommended amount of five servings daily. Participants in the intervention were instructed to consume CR equal to two fruit servings (36 g/d), replacing snacks with similar energy density twice during the day. Anthropometric and blood pressure measurements, assessment of dietary intake, and fasting blood draws were conducted at baseline and at week 24. Also, phenolic compounds present in CR were analyzed in plasma of the patients. t Test for parametric data and Mann-Whitney test or Wilcoxon test for non-parametric data were performed. Significance was set at P < 0.05. Results: Body weight, glycemic control, and lipid profile were not affected in either arm. Patients in the CR arm reduced their diastolic blood pressure and increased their total antioxidant potential significantly compared with baseline. The differences between the two groups at week 24 were significant. No change in high-sensitivity C-reactive protein was observed. A significant difference in plasma circulating p-hydroxybenzoic acid was observed between groups at the end of the trial.

Conclusions: Our study shows that naturally CR may improve health features in patients with well- controlled T2DM


https://www.academia.edu/85857355/A_pilot_randomized_controlled_trial_to_examine_the_health_outcomes_of_raisin_consumption_in_patients_with_diabetes


A Comprehensive review of raisins and raisin components and their relationship to human health

Abstract

Purpose

This literature review was performed to assess the effect of raisins on human health.

Methods

A review of Medline was conducted using the keywords: ‘raisins, raisins and health, raisins and cardiovascular disease (CVD), raisins and cancer, raisins and diabetes, raisins and fiber, raisins and colon health, raisins and antioxidants, raisins and inflammation, raisins and dental caries’. The reference lists from previous review articles on raisins and human health and the California Raisin Marketing Board files were reviewed for additional studies.

Results

Raisins have one of the highest polyphenolic content and antioxidant ORAC levels compared to other traditional dried fruits. Many of the polyphenols in raisins are well assimilated and bioavailable. Raisin consumption reduces low density lipoprotein (LDL) cholesterol, blood pressure and blood sugar, when compared to equal caloric carbohydrate snacks and is associated with a reduced risk of CVD. The anti-inflammatory and cancer chemopreventive effects of raisins are mixed. Raisin consumption reduces intestinal transit time and positively affects gut microbiota. Raisins produce sustained energy during long term athletic competitions equal to traditional sports energy gels, shots and jelly beans. Raisins produce a non-cariogenic oral environment and do not fit the American Academy of Pediatrics criteria to be considered a choking hazard.

Conclusions

Based on the review of literature, consumption of raisins provide numerous health benefits for promoting general wellness and in the prevention of many chronic diseases including: CVD, type 2 diabetes mellitus (T2DM) gastrointestinal diseases, and dental caries.


Keywords

raisins; health; diabetes; cardiovascular disease; antioxidants


https://e-jnh.org/DOIx.php?id=10.4163/jnh.2017.50.3.203



Mind-Blowing Benefits of Raisins For Skin & Hair You May Have No Idea About!


Are you guilty of picking all the raisins in the dry fruit mix and leaving none for others? Raisins are a delicacy, loved by many across the globe. Interesting fact: The word ‘raisins’ comes from the Latin word racemus which means a cluster of grapes or berries.


Some say that raisins were discovered by accident when they chanced upon a dried bunch of grapes thousands of years ago. Be what it may, we love raisins! They taste good and guess what? The benefits of raisins for skin and hair are so many!


The health-conscious and the smart, prefer to consume organic raisins that are grown without the use of any chemical fertilisers. The organic variety is the highest in terms of nutritional content.


RaisIN, Bad Skin & Hair OUT

If you were eating raisins only as a mini dessert, think again! The innumerable benefits of raisins for skin and hair are just mind-boggling! If you are sold and are now looking to buy a bunch of these juicy little wonders, buy the organic variety. Apart from its chemical-free cultivation method, organic farming is also great for the environment, the Indian farmer and your health.


https://www.24mantra.com/blogs/organic-lifestyle/mind-blowing-benefits-of-raisins-for-skin-hair-you-may-have-no-idea-about/


Raisins


Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as well as the cell line and animal model studies carried out to date. It has been demonstrated that raisins possess a low-to-moderate glycemic index, which makes them a healthy snack. They seem to contribute to a better diet quality and may reduce appetite. Their antioxidant capacity has been correlated to the phenolic content and this may be involved in the improvement of cardiovascular health. In addition, raisins maintain a good oral health due to their antibacterial activity, low adherence to teeth and an optimum oral pH. Raisin consumption also seems to be favorable for colon function, although more studies should be done to conclude this benefit. Moreover, gut microbiota could be affected by the prebiotic content of raisins. Cell line and animal model studies show other potential benefits in specific diseases, such as cancer and Alzheimer’s disease. However, deeper research is required and future intervention studies with humans are needed. Overall, incorporating an 80–90 g portion of raisins (half a cup) into the daily diet may be favorable for human health.


https://encyclopedia.pub/entry/207




Raisins in human health: A review


Abstract and Figures

In the last years, the scientific research in the field of non-alcoholic grape products has increased significantly. Raisins are often evaluated negatively from the nutritional point of view, mainly for their high sugar content. On the other hand, some in vitroand in vivo studies have suggested that raisins could have healthy effects due to their positive phytochemical profile. The aim of this work was the collection of scientific studies performed in humans to assess critically the health-promoting effects of raisins, as a part of the normal/Mediterranean diet. In most cases, the beneficial effects of raisins have been assessed in intervention studies focused on cardiovascular area, diabetes and oral health, where a decrease in postprandial glycemia and insulinemia both in diabetic and healthy subjects has been observed. The positive effects were generally evident after a short-term consumption of about 70 g/die of raisins in comparison to a similar quantity of snacks or glucose solution. Surprisingly, some positive findings were shown in oral health. On these bases several findings support the suitability of raisins as a source of healthy compounds for human diet, but limits in the data published till now clearly support the need of new specifically designed trials.


https://www.researchgate.net/publication/309469046_Raisins_in_human_health_A_review


Raisins in Natural Remedies for Stress and Anxiety


The famous Arab proverb, "Life is like a handful of raisins: sweet with a touch of bitterness" masterfully speaks volumes of our daily struggles. We often forget to pay attention to our mental health, especially when we're on-the-go. As a mindfulness enthusiast, I always seek natural remedies to fortify my armor against stress and anxiety. So, imagine my delight when I stumbled across the versatile benefits of raisins in traditional medicine for calming our frazzled nerves.


Granny's Secret - A Personal Anecdote:

Growing up, I remember Grandma always sneaking in raisins to our meals, frequently compared to our family's little secret ingredient; now, not only do they enliven my taste buds, but my mental health as well. Grandma once said, "Raisins bring comfort, like a warm and gentle hug" - little did I know that her golden words carried tremendous healing power.


Raisin' the Bar for Stress & Anxiety Relief:

To add a crunch of intriguing facts - archeological evidences suggest that raisins have been consumed since 4000 BC as a primary food source, a sweet treat, and even as currency! The sweet and chewy goodness of raisins aren't their only virtues. These tiny gems pack a nutritional punch - bursting with vitamins, fiber, iron, and potassium.


https://theraisinshut.com/blogs/the-raisins-hut/raisins-in-natural-remedies-for-stress-and-anxiety




Raisins – Health Benefits, Uses and Important Facts


Health benefits of raisins:

Aids digestion


Raisins' higher fiber content makes them beneficial for digestive health. In addition, they have laxative properties of their own. Moreover, raisins help with heartburn, gas, and bloating. If you have trouble going to the bathroom or suffering from constipation, try eating raisins (soaked raisins) first thing in the morning.


Helps your eyesight


Polyphenolic phytonutrients, including vitamin A, carotenoid, and beta carotene, can be found in raisins. That's why they're good for your eyes. All of these components work together to prevent cataracts, macular degeneration, and other vision-threatening side effects of free radical damage.


Regulates Blood Pressure


Raisins, which are high in potassium but low in sodium, are known to have a vasodilatory effect. The salt levels in your body can be maintained with the help of raisins.


Increase Your Bone Density


Raisins strengthen bones because of the high calcium content they contain. The mineral boron plays a crucial role in maintaining healthy bones. Boron can be found in abundance in raisins. Soaked raisins, according to a number of medical studies, increase bone density and strength.


https://www.potsandpans.in/blogs/articles/raisins-health-benefits-uses-and-important-facts


Health Benefits Raisins, Types and Nutritional facts


High sugar foods are tempting, but they also bring along various lifestyle diseases with them. It is hard to choose minimally processed food from the vast list of mouth-watering foods. Are you having a sweet tooth and still want to be healthy? No worries, our saviour raisins are here!


Raisins, also known as dried grapes, are ideal. They have no added preservatives and are minimally processed. However, their high calorie and sugar content are a drawback.


What are raisins?


Raisins are fermented grapes. Reddish-brown colour is their identity, but they are also available in golden colour.


Traditional raisins are usually sun-dried with no added preservatives. The brown colour of the fruit is due to the air-drying process.



Benefits of raisins for skin

It is known that raisins benefit overall health and their role in skin health is significant. Consuming raisin and raisin water is advantageous to the skin.


Raisins help to keep the skin clear and rejuvenated for a long time.


Raisin water is beneficial for skin hydration and nourishes the skin from within.


It is also effective for protecting skin cells by guarding against skin damage.


Regular consumption of raisins helps with premature skin ageing. It aids in the reduction of fine lines, ageing spots, blemishes and wrinkles.


Raisins are effective at keeping acne at bay.


https://www.starhealth.in/blog/health-benefits-raisins



Health Benefits of Raisins And Its Side Effects


Raisin is a small fruit that is packed with a lot of health benefits. You can start consuming raisin for increasing libido and sperm motility and is a known food for treating erectile dysfunction. The fruit is known for its laxative property.

Check out health benefits of eating raisins, this natural food that helps in curing and treating constipation. This is a fruit that old aged people can eat. The bloating and the high acidity effect that one experiences after eating heavy food are greatly reduced when raisins are consumed. People suffering from low blood levels and low production of red blood cells will benefit a lot if they have raisins.

Eating Raisins or kishmish is beneficial for pregnant women as well. The high antioxidant property of raisins makes them a hero in stopping infections and fever. The common cold is kept at bay when raisins are taken on a regular basis.

Many people also suffer from low energy levels can eat raisins which are good for releasing energy as they have high doses of carbohydrates. Hair growth and retention of hair shine are seen when raisins are consumed, and they are surely a healthy snack.



https://www.lybrate.com/topic/raisins-benefits

Association of raisin consumption with nutrient intake, diet quality, and health risk factors in US adults: National Health and Nutrition Examination Survey 2001–2012


ABSTRACT

Raisins are one of the most commonly consumed dried fruits. Because of their unique nutrient profile, raisins may have some distinctive health benefits. The purpose of this study was to examine the cross-sectional association between raisin consumption and nutrient intake, dietary quality, body weight, and metabolic syndrome risk factors in adults. Data from the National Health and Nutrition Examination Survey (NHANES), 2001–2012 (n = 29,684) were used. Raisin consumers (n = 458, 60% female) were defined as those having any amount of raisins during the first 24 h dietary recall. Diet quality was calculated using the Healthy Eating Index-2010 (HEI-2010). Covariate (demographic and lifestyle)-adjusted regression analyses were conducted using appropriate sample weights and significance was set at p < 0.01. Raisin consumers had higher intakes of energy (9%); higher intakes of ‘nutrients of public health concern/shortfall nutrients’, such as dietary fiber (34%), potassium (16%), magnesium (22%), vitamin C (24%), and vitamin E (22%); and lower intakes of ‘nutrients to limit’, such as added sugar (−17%), saturated fat (−15%), and sodium (−10%), than non-consumers. No associations were observed for intakes of calcium, iron, vitamin A, vitamin D, and folate. Consumers had higher intakes of total fruit (72%), whole fruit (111%), vegetables (22%), and whole grains (109%), and had a higher diet quality, as indicated by 25% higher total HEI-2010 scores than non-consumers. Compared to non-consumers, raisin consumers had a lower body weight (−4.2%), body mass index (−5.2%), and waist circumference (−3.8%), were 39% less likely to be overweight or obese, and had a 54% reduced risk of metabolic syndrome. In conclusion, raisin consumption was associated with better nutrient intake, diet quality, and weight parameters, and with lower risk of being obese and having metabolic syndrome in US adults.


KEYWORDS: NHANES, raisins, Healthy Eating Index, body weight, BMI, obesity, metabolic syndrome


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642187/

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